Identification of chlorpromazine

Molecular Formula: C17H19CLN2S.HCL

Molecular Mass: 355.3

Chemical Name: 2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine monohydrochloride                                 or 2-Chloro-N,N-dimethyl-10H –phenothiazine-10-peopanamine monohydrochloride

General Requirement: chlorpromazine hydrochloride contains not less than 98.0% and not more than 101.0% of C17H19CLN2S.HCL , calculated with reference to the dried substance

Assay:(1) 

Dissolve about 0.7g, accurately weighted, in 20ml of acetone ,add 10ml of mercuric acetate/acetic acid and 3ml of methyl orange/acetone, and titrate with perchloric acid (0.1M) VS as described under "Non-aqueous titration